Wait are you talking about a mouse then or are you talking about a mouse pad where you have a pad to the right of you and you have pen to write? If it is a mouse try this :
My first suggestion is too download the latest drivers from the mouses home website. After doing that you may want to check the settings for the mouse by going to the Control Panel ----> Mouse, see if there is anything you maybe able to tweak to fix that. The next thing I would check out is downloading TweakUI by Windows and see if you can't change some settings in that if that is the problem. I would then suggest using the mouses on another computer too see if that has anything to do with, but it looks like you have already done that, so it sounds like there maybe a problem with the computer itself...
TweakUI
I will see if I can't come up with some more information later. This should keep you busy for right now if oyu haven't tryed any of this first...
Rat